Drug General Information
Drug ID	D05LCX
Former ID	DIB012151
Drug Name	A-70276
Synonyms	A-71134
Indication	Gastrointestinal disease [ICD10:K00-K93]		Terminated	[545481]
Company	Abbott Laboratories
Structure		Download 2D MOL 3D MOL
Canonical SMILES	n1c2c(c(cc1C(=O)N[C@@H](C(=O)N(CCCCC)CCCCC)Cc1c[nH]c3c1<br />cccc3)O)cccc2O
CAS Number	CAS 127387-81-9
Target and Pathway
Target(s)	Cholecystokinin receptor type A	Target Info	Modulator	[528964]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Insulin secretion
	Pancreatic secretion
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545481	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003433)
Ref 528964	Cholecystokinin antagonists: (R)-tryptophan-based hybrid antagonists of high affinity and selectivity for CCK-A receptors. J Med Chem. 1991 Dec;34(12):3350-9.

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