Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05KUP
|
||||
| Former ID |
DIB009340
|
||||
| Drug Name |
ERB-257
|
||||
| Indication | Sepsis [ICD9: 995.91; ICD10:A40, A41] | Phase 1 | [1] | ||
| Company |
Wyeth
|
||||
| Target and Pathway | |||||
| Target(s) | Estrogen receptor beta | Target Info | Agonist | [2] | |
| KEGG Pathway | Estrogen signaling pathway | ||||
| Prolactin signaling pathway | |||||
| Pathway Interaction Database | Plasma membrane estrogen receptor signaling | ||||
| Validated nuclear estrogen receptor beta network | |||||
| Validated nuclear estrogen receptor alpha network | |||||
| Reactome | Nuclear Receptor transcription pathway | ||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Ovarian Infertility Genes | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Nuclear Receptors | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00722202) Study Evaluating the Safety and Pharmacokinetics (PK) of Ascending Single IV Doses of ERB-257 in Healthy Japanese Males. U.S. National Institutes of Health. | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030075) | ||||
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