Drug Information

Drug General Information
Drug ID
D05JET
Former ID
DPR000126
Drug Name
Remacemide
Synonyms
Remacemida; Remacemidum; Remacemide [INN]; FPL 12924; FPL 12924AA; FPL 14144; FPL 14145; FPL-12944AA; PR 1032-644; PR 934-423; PR1032-646; Remacemida [INN-Spanish]; Remacemidum [INN-Latin]; PR-934-423; Remacemide monohydrochloride, (+-)-isomer; (+)-2-Amino-N-(1-methyl-1,2-diphenylethyl)acetamide; (+-)-2-Amino-N-(1-methyl-1,2-diphenylethyl)acetamide; (-)-2-Amino-N-(1-methyl-1,2-diphenylethyl)acetamide; 2-amino-N-(1,2-diphenylpropan-2-yl)acetamide; 2-amino-N-(1-methyl-1,2-diphenylethyl)acetamide
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Phase 3 [534082]
Company
Astra Zeneca
Structure
Download
2D MOL

3D MOL
Formula
C17H20N2O
Canonical SMILES
CC(CC1=CC=CC=C1)(C2=CC=CC=C2)NC(=O)CN
InChI
1S/C17H20N2O/c1-17(19-16(20)13-18,15-10-6-3-7-11-15)12-14-8-4-2-5-9-14/h2-11H,12-13,18H2,1H3,(H,19,20)
InChIKey
YSGASDXSLKIKOD-UHFFFAOYSA-N
CAS Number
CAS 128298-28-2
PubChem Compound ID
60511
PubChem Substance ID
6257068, 8186897, 14848312, 43117902, 49858030, 49858031, 49858032, 50787713, 57314025, 85788157, 90490603, 92729779, 103199491, 104320951, 125823975, 126682339, 129840666, 131297093, 135047599, 135203406, 135203407, 142472738, 173894588, 179080708, 179577889, 203098689, 223657235, 226516225, 249995109, 252770057
Target and Pathway
Target(s) NMDA receptor Target Info Agonist [535658], [536166]
References
Ref 534082Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine metabolite. J Pharmacol Exp Ther. 1996 Jan;276(1):161-8.
Ref 535658Neuroprotective agents for the treatment of acute ischemic stroke. Curr Neurol Neurosci Rep. 2003 Jan;3(1):9-20.
Ref 536166Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.

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