Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05GOM
|
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| Former ID |
DIB000570
|
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| Drug Name |
S-20928
|
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| Drug Type |
Small molecular drug
|
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| Indication | Sleep disorders [ICD9: 307.4, 327, 780.5; ICD10:F51, G47] | Terminated | [1], [2] | ||
| Company |
Servier
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C17H19NO
|
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| InChI |
InChI=1S/C17H19NO/c19-17(15-8-4-9-15)18-12-11-14-7-3-6-13-5-1-2-10-16(13)14/h1-3,5-7,10,15H,4,8-9,11-12H2,(H,18,19)
|
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| InChIKey |
GLXSBZGTGMPDKH-UHFFFAOYSA-N
|
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| CAS Number |
CAS 152302-33-5
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Melatonin receptor | Target Info | Modulator | [3] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Circadian entrainment | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Small Ligand GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1360). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006913) | ||||
| REF 3 | Effects of two melatonin analogues, S-20098 and S-20928, on melatonin receptors in the pars tuberalis of the rat. J Pineal Res. 1998 Oct;25(3):172-6. | ||||
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