Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05GKD
|
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| Former ID |
DAP000140
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| Drug Name |
Tramadol
|
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| Synonyms |
Conzip; Ryzolt; Tramadol Hydrochloride; Ultram Er; Rybix Odt; Ultram; Ultram
|
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| Drug Type |
Small molecular drug
|
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| Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Approved | [1], [2] | ||
| Therapeutic Class |
Analgesics
|
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| Company |
Chemie Grunenthal of Stolberg-am-Rhein
|
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| Structure |
|
Download2D MOL |
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| Formula |
C16H25NO2
|
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| InChIKey |
TVYLLZQTGLZFBW-UHFFFAOYSA-N
|
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| CAS Number |
CAS 27203-92-5
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
5658598, 8153398, 15221636, 29224565, 49958171, 49958172, 49958173, 50837838, 85209685, 103113054, 104309473, 117617520, 123083206, 125679912, 126682485, 129321889, 134995846, 135060961, 137010486, 142192184, 162831124, 164174929, 164765703, 164765706, 179225203, 184526607, 184596120, 216106831, 223656715, 223766038, 226439878, 241058775, 244533735, 249923528, 252166498
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| SuperDrug ATC ID |
N02AX02
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| SuperDrug CAS ID |
cas=027203925
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 2C receptor | Target Info | Modulator | [3] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Serotonergic synapse | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| PANTHER Pathway | 5HT2 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Local effect of tramadol on formalin evoked flinching behavior in rats. Rev Bras Anestesiol. 2008 Jul-Aug;58(4):375-9, 371-5. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8286). | ||||
| REF 3 | The inhibitory effects of tramadol on 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes. Anesth Analg. 2004 May;98(5):1401-6, table of contents. | ||||
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