Drug Information

Drug General Information
Drug ID
D05FUY
Former ID
DNC005581
Drug Name
1,8-Dichloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527584]
Structure
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2D MOL

3D MOL
Formula
C16H10Cl2O2
Canonical SMILES
C1=CC(=CC=C1C2=CC(=C3C(=C2)C=CC(=C3Cl)O)Cl)O
InChI
1S/C16H10Cl2O2/c17-13-8-11(9-1-4-12(19)5-2-9)7-10-3-6-14(20)16(18)15(10)13/h1-8,19-20H
InChIKey
YTFVBUBYMJJWQZ-UHFFFAOYSA-N
PubChem Compound ID
10149584
Target and Pathway
Target(s) Estrogen receptor Target Info Inhibitor [527584]
Estrogen receptor beta Target Info Inhibitor [527584]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Proteoglycans in cancerhsa04915:Estrogen signaling pathway
NetPath Pathway FSH Signaling Pathway
EGFR1 Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
Plasma membrane estrogen receptor signaling
LKB1 signaling events
Regulation of Telomerase
ATF-2 transcription factor network
AP-1 transcription factor network
FOXM1 transcription factor network
Validated nuclear estrogen receptor alpha network
Signaling mediated by p38-alpha and p38-beta
FOXA1 transcription factor networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
Validated nuclear estrogen receptor beta network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways Estrogen signaling pathway
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
Signaling by ERBB4
JAK/STAT
Integrated Pancreatic Cancer Pathway
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
Integrated Breast Cancer Pathway
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
Ovarian Infertility Genes
Nuclear Receptors
References
Ref 527584J Med Chem. 2005 Jun 16;48(12):3953-79.ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity.
Ref 527584J Med Chem. 2005 Jun 16;48(12):3953-79.ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity.

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