| Drug General Information |
| Drug ID |
D05FGR
|
| Former ID |
DNC006444
|
| Drug Name |
R-flurbiprofen
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Phase 2 |
[1],
[2]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C15H13FO2
|
| InChI |
InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m1/s1
|
| InChIKey |
SYTBZMRGLBWNTM-SNVBAGLBSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
520769, 803799, 841054, 10225348, 11112562, 11114208, 12015300, 14749662, 15196534, 24775785, 24878847, 44423182, 50100872, 57335240, 74982718, 91699354, 96025693, 99206222, 103459354, 104058528, 104407155, 119526881, 124757425, 124883374, 124883378, 124883379, 125164229, 126531730, 126687010, 129308098, 131316938, 134343649, 135049354, 135659612, 137001902, 152030647, 162037701, 163126955, 175267390, 175269361, 175426967, 176484699, 178103912, 184531631, 223672082, 224564111, 226414056, 241090976, 249773516, 251890381
|
| Target and Pathway |
| Target(s) |
Gamma-secretase |
Target Info |
Inhibitor |
[3]
|
|---|
| Beta-secretase |
Target Info |
Inhibitor |
[3]
|
| Presenilin 2 |
Target Info |
Inhibitor |
[3]
|
| Presenilin 1 |
Target Info |
Inhibitor |
[3]
|
|
KEGG Pathway
|
Notch signaling pathway
|
|
Alzheimer's diseasehsa04330:Notch signaling pathway
|
|
Neurotrophin signaling pathway
|
|
Alzheimer's diseasehsa04310:Wnt signaling pathway
|
|
Alzheimer's disease
|
|
NetPath Pathway
|
Notch Signaling Pathway
|
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Alzheimer disease-presenilin pathway
|
|
Notch signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
|
Notch signaling pathway
|
|
Pathway Interaction Database
|
Notch signaling pathway
|
|
Presenilin action in Notch and Wnt signaling
|
|
p75(NTR)-mediated signaling
|
|
Syndecan-3-mediated signaling eventslkb1_pathway:LKB1 signaling eventsnotch_pathway:Notch signaling pathway
|
|
Syndecan-3-mediated signaling events
|
|
Reactome
|
Nuclear signaling by ERBB4
|
|
Regulated proteolysis of p75NTR
|
|
NRIF signals cell death from the nucleus
|
|
Activated NOTCH1 Transmits Signal to the Nucleus
|
|
Constitutive Signaling by NOTCH1 PEST Domain Mutants
|
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Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
|
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NOTCH2 Activation and Transmission of Signal to the Nucleus
|
|
EPH-ephrin mediated repulsion of cellsR-HSA-1251985:Nuclear signaling by ERBB4
|
|
EPH-ephrin mediated repulsion of cellsR-HSA-1474228:Degradation of the extracellular matrix
|
|
WikiPathways
|
Notch Signaling Pathway
|
|
Signaling by ERBB4
|
|
Signaling by NOTCH3
|
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Signaling by NOTCH4
|
|
Signaling by NOTCH1
|
|
Signaling by NOTCH2
|
|
Notch Signaling Pathway
|
|
Signalling by NGFWP61:Notch Signaling Pathway
|
|
Alzheimers Disease
|
| References |
| REF 1 | ClinicalTrials.gov (NCT00045123) R-Flurbiprofen in Treating Patients With Localized Prostate Cancer at Risk of Recurrence. U.S. National Institutes of Health. |
|---|
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7340). |
|---|
| REF 3 | Bioorg Med Chem Lett. 2006 Apr 15;16(8):2219-23. Epub 2006 Feb 7.The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent. |
|---|
