Drug Information
Drug General Information | |||||
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Drug ID |
D05EQG
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Former ID |
DIB018414
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Drug Name |
[3H]spiperone
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Synonyms |
[3H]-spiperone
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [540262] | ||
Structure |
Download2D MOL |
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Formula |
C23H26FN3O2
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InChI |
InChI=1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29)
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InChIKey |
DKGZKTPJOSAWFA-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | D(3) dopamine receptor | Target Info | Antagonist | [525818] | |
D(4) dopamine receptor | Target Info | Antagonist | [533735] | ||
D(2) dopamine receptor | Target Info | Antagonist | [525818] | ||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
Dopamine receptor mediated signaling pathway | |||||
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
Nicotine pharmacodynamics pathway | |||||
References | |||||
Ref 525818 | Regulation of human D(1), d(2(long)), d(2(short)), D(3) and D(4) dopamine receptors by amiloride and amiloride analogues. Br J Pharmacol. 2000 Jul;130(5):1045-59. | ||||
Ref 533735 | Differential effects of [3H]nemonapride and [3H]spiperone binding on human dopamine D4 receptors. Neurosci Lett. 1995 Feb 17;186(2-3):145-8. |
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