Drug Information
Drug General Information | |||||
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Drug ID |
D05ECA
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Former ID |
DIB009583
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Drug Name |
LJM716
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Drug Type |
Antibody
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Indication | Breast cancer [ICD9: 174, 175; ICD10:C50] | Phase 1/2 | [1] | ||
Company |
Novartis pharmaceuticals
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Target and Pathway | |||||
Target(s) | Receptor protein-tyrosine kinase erbB-3 | Target Info | [2] | ||
KEGG Pathway | ErbB signaling pathway | ||||
Calcium signaling pathway | |||||
Endocytosis | |||||
Proteoglycans in cancer | |||||
MicroRNAs in cancer | |||||
NetPath Pathway | TNFalpha Signaling Pathway | ||||
PANTHER Pathway | Cadherin signaling pathway | ||||
EGF receptor signaling pathway | |||||
Pathway Interaction Database | ErbB2/ErbB3 signaling events | ||||
ErbB receptor signaling network | |||||
a6b1 and a6b4 Integrin signaling | |||||
WikiPathways | ErbB Signaling Pathway | ||||
Apoptosis-related network due to altered Notch3 in ovarian cancer | |||||
Signaling Pathways in Glioblastoma | |||||
miR-targeted genes in muscle cell - TarBase | |||||
Heart Development | |||||
References | |||||
REF 1 | ClinicalTrials.gov (NCT02143622) Study of Efficacy and Safety of LJM716 and Cetuximab in Head and Neck Squamous Cell Carcinoma Patients. U.S. National Institutes of Health. | ||||
REF 2 | An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Cancer Res. 2013 Oct 1;73(19):6024-35. | ||||
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