Drug Information

Drug General Information
Drug ID
D04WWO
Former ID
DNC014796
Drug Name
IM-491
Drug Type
Small molecular drug
Indication Discovery agent Investigative [1]
Structure
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2D MOL

3D MOL
Formula
C25H28N4O4
Canonical SMILES
CC1=NC2=CC=CC=C2C(=C1)COC3=CC=C(C=C3)NC(=O)C4C(CCCN4C)C<br />(=O)NO
InChI
1S/C25H28N4O4/c1-16-14-17(20-6-3-4-8-22(20)26-16)15-33-19-11-9-18(10-12-19)27-25(31)23-21(24(30)28-32)7-5-13-29(23)2/h3-4,6,8-12,14,21,23,32H,5,7,13,15H2,1-2H3,(H,27,31)(H,28,30)/t21-,23-/m0/s1
InChIKey
RJSKOAOWDAMMHR-GMAHTHKFSA-N
PubChem Compound ID
9889867
Target and Pathway
Target(s) ADAM 17 Target Info Inhibitor [1]
KEGG Pathway Notch signaling pathway
Alzheimer's disease
Epithelial cell signaling in Helicobacter pylori infection
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Alzheimer disease-presenilin pathway
Notch signaling pathway
Pathway Interaction Database ErbB4 signaling events
TNF receptor signaling pathway
p75(NTR)-mediated signaling
Reactome Nuclear signaling by ERBB4
Collagen degradation
Regulated proteolysis of p75NTR
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7
M1580_K2555) Translocation Mutant
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
TNF signaling
Growth hormone receptor signaling
WikiPathways Notch Signaling Pathway
Copper homeostasis
Notch Signaling Pathway
Growth hormone receptor signaling
BDNF signaling pathway
Alzheimers Disease
Signalling by NGF
Extrinsic Pathway for Apoptosis
References
REF 1Bioorg Med Chem Lett. 2008 Jan 1;18(1):241-6. Epub 2007 Oct 30.Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors.

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