| Drug General Information |
| Drug ID |
D04WFN
|
| Former ID |
DIB019096
|
| Drug Name |
NU6140
|
| Synonyms |
NU6140
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C23H30N6O2
|
| InChI |
InChI=1S/C23H30N6O2/c1-3-29(4-2)22(30)17-10-12-18(13-11-17)26-23-27-20-19(24-15-25-20)21(28-23)31-14-16-8-6-5-7-9-16/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,25,26,27,28)
|
| InChIKey |
XHEQSRJCJTWWAH-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
15200601, 26758510, 40316993, 53790648, 53800809, 78774062, 99302686, 134440301, 135276106, 136354610, 143179854, 163122852, 163688326, 175607473, 178102572, 180438581, 204377877, 208265019, 228302626, 241376370, 246654087, 249617822, 252157174
|
| Target and Pathway |
| Target(s) |
Cell division protein kinase 5 |
Target Info |
Inhibitor |
[1]
|
|---|
| Cell division protein kinase 2 |
Target Info |
Inhibitor |
[1]
|
| Cell division protein kinase 7 |
Target Info |
Inhibitor |
[1]
|
| Cell division control protein 2 homolog |
Target Info |
Inhibitor |
[1]
|
| Cell division protein kinase 4 |
Target Info |
Inhibitor |
[1]
|
| Interferon-induced, double-stranded RNA-activated protein kinase |
Target Info |
Inhibitor |
[2]
|
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KEGG Pathway
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Axon guidance
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Alzheimer's disease
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Cocaine addictionhsa04068:FoxO signaling pathway
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Cell cycle
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Oocyte meiosis
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p53 signaling pathway
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PI3K-Akt signaling pathway
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Progesterone-mediated oocyte maturation
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Hepatitis B
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Measles
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Herpes simplex infection
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Epstein-Barr virus infection
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Pathways in cancer
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Viral carcinogenesis
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Prostate cancer
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Small cell lung cancerhsa03022:Basal transcription factors
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Nucleotide excision repair
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Cell cyclehsa04110:Cell cycle
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Gap junction
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Viral carcinogenesishsa04110:Cell cycle
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Tight junction
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T cell receptor signaling pathway
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HTLV-I infection
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Pancreatic cancer
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Glioma
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Melanoma
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Bladder cancer
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Chronic myeloid leukemia
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Small cell lung cancer
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Non-small cell lung cancer
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NetPath Pathway
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EGFR1 Signaling Pathway
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TCR Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
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RANKL Signaling PathwayNetPath_21:RANKL Signaling PathwayNetPath_11:TCR Signaling Pathway
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RANKL Signaling Pathway
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PANTHER Pathway
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Axon guidance mediated by semaphorinsP00059:p53 pathway
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p53 pathway feedback loops 2P00006:Apoptosis signaling pathway
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Pathway Interaction Database
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Reelin signaling pathway
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Glucocorticoid receptor regulatory network
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Lissencephaly gene (LIS1) in neuronal migration and development
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EPHA forward signaling
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Trk receptor signaling mediated by the MAPK pathwaysmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
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Signaling events mediated by PRL
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p73 transcription factor network
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E2F transcription factor network
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ATR signaling pathway
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mTOR signaling pathway
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IL2-mediated signaling events
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FoxO family signaling
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FOXM1 transcription factor network
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BARD1 signaling events
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p53 pathway
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Regulation of retinoblastoma proteinretinoic_acid_pathway:Retinoic acid receptors-mediated signalingp73pathway:p73 transcription factor network
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PLK1 signaling events
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AP-1 transcription factor network
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Retinoic acid receptors-mediated signalingsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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Validated targets of C-MYC transcriptional activation
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ATF-2 transcription factor network
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Regulation of retinoblastoma proteintcptp_pathway:Signaling events mediated by TCPTP
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Ceramide signaling pathway
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PDGFR-beta signaling pathway
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Reactome
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DARPP-32 events
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CRMPs in Sema3A signaling
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Factors involved in megakaryocyte development and platelet productionR-HSA-1538133:G0 and Early G1
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Activation of ATR in response to replication stress
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Regulation of APC/C activators between G1/S and early anaphase
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SCF(Skp2)-mediated degradation of p27/p21
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Senescence-Associated Secretory Phenotype (SASP)
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DNA Damage/Telomere Stress Induced Senescence
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Processing of DNA double-strand break ends
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G2 Phase
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Orc1 removal from chromatin
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Cyclin E associated events during G1/S transition
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Cyclin A/B1 associated events during G2/M transition
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p53-Dependent G1 DNA Damage Response
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Cyclin A:Cdk2-associated events at S phase entry
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Meiotic recombination
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Factors involved in megakaryocyte development and platelet productionR-HSA-427413:NoRC negatively regulates rRNA expression
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Formation of TC-NER Pre-Incision Complex
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Dual incision in TC-NER
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Gap-filling DNA repair synthesis and ligation in TC-NER
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Cyclin D associated events in G1
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RNA Polymerase I Transcription InitiationR-HSA-110056:MAPK3 (ERK1) activation
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E2F mediated regulation of DNA replication
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G0 and Early G1
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Cyclin B2 mediated events
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Golgi Cisternae Pericentriolar Stack Reorganization
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Cdc20:Phospho-APC/C mediated degradation of Cyclin A
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Phosphorylation of the APC/C
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Phosphorylation of Emi1
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Condensation of Prophase Chromosomes
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MASTL Facilitates Mitotic Progression
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Resolution of Sister Chromatid Cohesion
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Condensation of Prometaphase Chromosomes
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Regulation of PLK1 Activity at G2/M Transition
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Activation of NIMA Kinases NEK9, NEK6, NEK7
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Loss of Nlp from mitotic centrosomes
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Recruitment of mitotic centrosome proteins and complexes
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Loss of proteins required for interphase microtubule organization?from the centrosome
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Recruitment of NuMA to mitotic centrosomes
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Depolymerisation of the Nuclear Lamina
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Anchoring of the basal body to the plasma membrane
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MAPK6/MAPK4 signaling
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G1/S-Specific Transcription
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G2/M DNA replication checkpoint
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Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-2559580:Oxidative Stress Induced Senescence
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Oncogene Induced Senescence
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RMTs methylate histone arginines
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Transcriptional regulation of white adipocyte differentiation
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Ubiquitin-dependent degradation of Cyclin D1
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Meiotic recombinationR-HSA-1169408:ISG15 antiviral mechanism
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WikiPathways
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DNA Damage Response
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BDNF signaling pathway
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Alzheimers Disease
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Opioid Signalling
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Semaphorin interactions
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Factors involved in megakaryocyte development and platelet production
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Nicotine Activity on Dopaminergic Neurons
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miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
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ID signaling pathway
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DNA Replication
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G1 to S cell cycle control
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M/G1 Transition
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S Phase
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Meiotic Recombination
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Aryl Hydrocarbon Receptor
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ATM Signaling Pathway
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Retinoblastoma (RB) in Cancer
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Spinal Cord Injury
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Integrated Pancreatic Cancer Pathway
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Oncostatin M Signaling Pathway
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Prostate Cancer
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Signaling Pathways in Glioblastoma
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TSH signaling pathway
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Integrated Breast Cancer Pathway
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Integrated Cancer pathway
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Synthesis of DNA
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Regulation of DNA replication
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Mitotic G2-G2/M phases
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Mitotic G1-G1/S phases
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Cell Cycle
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APC/C-mediated degradation of cell cycle proteins
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Cell Cycle Checkpoints
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miRNA Regulation of DNA Damage ResponseWP45:G1 to S cell cycle control
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Eukaryotic Transcription Initiation
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Cardiac Hypertrophic Response
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HIV Life Cycle
|
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Nucleotide Excision Repair
|
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RNA Polymerase II Transcription
|
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RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
|
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mRNA Capping
|
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MicroRNAs in cardiomyocyte hypertrophyWP707:DNA Damage Response
|
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TGF beta Signaling Pathway
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PPAR Alpha Pathway
|
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MAP kinase activation in TLR cascade
|
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RAF/MAP kinase cascade
|
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Mitotic Prophase
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Mitotic Prometaphase
|
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BMI1
|
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Regulation of Microtubule Cytoskeleton
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Ovarian Infertility Genes
|
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Bladder Cancer
|
|
Transcriptional Regulation of White Adipocyte Differentiation
|
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miRNA Regulation of DNA Damage ResponseWP619:Type II interferon signaling (IFNG)
|
|
Host Interactions with Influenza Factors
|
|
Translation Factors
|
| References |
| REF 1 | Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005 Sep;4(9):1328-37. |
|---|
| REF 2 | Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4108-14. |
|---|
