Drug General Information
Drug ID
D04VWJ
Former ID
DCL000053
Drug Name
ARRY-520
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 2 [524532]
Therapeutic Class
Anticancer Agents
Company
Array BioPharma.
Structure
Download
2D MOL

3D MOL

Formula
C20H22F2N4O2S
Canonical SMILES
CN(C(=O)N1C(SC(=N1)C2=C(C=CC(=C2)F)F)(CCCN)C3=CC=CC=C3)<br />OC
InChI
1S/C20H22F2N4O2S/c1-25(28-2)19(27)26-20(11-6-12-23,14-7-4-3-5-8-14)29-18(24-26)16-13-15(21)9-10-17(16)22/h3-5,7-10,13H,6,11-12,23H2,1-2H3/t20-/m0/s1
InChIKey
LLXISKGBWFTGEI-FQEVSTJZSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Kinesin-like protein KIF11 Target Info Inhibitor [536588], [537357]
Reactome MHC class II antigen presentation
Kinesins
WikiPathways MHC class II antigen presentation
Kinesins
References
Ref 524532ClinicalTrials.gov (NCT01989325) A Study of Filanesib (ARRY-520) and Carfilzomib in Patients With Advanced Multiple Myeloma. U.S. National Institutes of Health.
Ref 536588Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Nov;29(9):625-55.
Ref 537357Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells. Leukemia. 2009 May 21.

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