Drug Information

Drug General Information
Drug ID
D04VIP
Former ID
DIB002061
Drug Name
4030W92
Synonyms
BW-4030W92; 5-(2,3-Dichlorophenyl)-6-(fluoromethyl)pyrimidine-2,4-diamine
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Discontinued in Phase 2 [546124]
Structure
Download
2D MOL

3D MOL
Formula
C11H9Cl2FN4
Canonical SMILES
C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=C2N)N)CF
InChI
1S/C11H9Cl2FN4/c12-6-3-1-2-5(9(6)13)8-7(4-14)17-11(16)18-10(8)15/h1-3H,4H2,(H4,15,16,17,18)
InChIKey
GKBLWFDYSYTVEA-UHFFFAOYSA-N
PubChem Compound ID
9860692
PubChem Substance ID
14824691, 24153778, 45282978, 77211184, 127965196, 137211649, 140110102, 163641510, 163641932, 198964611, 225074429, 226649593
Target and Pathway
Target(s) Sodium channel Target Info Modulator [527123], [551871]
KEGG Pathway Dopaminergic synapse
Reactome Interaction between L1 and Ankyrins
References
Ref 546124Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006453)
Ref 527123Lack of effect of two oral sodium channel antagonists, lamotrigine and 4030W92, on intradermal capsaicin-induced hyperalgesia model. Pharmacol Biochem Behav. 2004 Jun;78(2):349-55.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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