Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04VDY
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| Former ID |
DNC004436
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| Drug Name |
L-741671
|
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| Drug Type |
Small molecular drug
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| Indication | Emesis [ICD9: 787; ICD10:R11] | Terminated | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C23H22F6N4O2
|
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| Canonical SMILES |
C1CC(C(N(C1)CC2=NC(=O)NN2)C3=CC=CC=C3)OCC4=CC(=CC(=C4)C<br />(F)(F)F)C(F)(F)F
|
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| InChI |
1S/C23H22F6N4O2/c24-22(25,26)16-9-14(10-17(11-16)23(27,28)29)13-35-18-7-4-8-33(12-19-30-21(34)32-31-19)20(18)15-5-2-1-3-6-15/h1-3,5-6,9-11,18,20H,4,7-8,12-13H2,(H2,30,31,32,34)/t18-,20-/m0/s1
|
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| InChIKey |
ZUWHBRRBKKTMQO-ICSRJNTNSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Substance-P receptor | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Measles | |||||
| PANTHER Pathway | CCKR signaling map ST | ||||
| Reactome | G alpha (q) signalling events | ||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Spinal Cord Injury | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009849) | ||||
| REF 2 | J Med Chem. 1996 Jul 19;39(15):2907-14.N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: a novel class of potent orally active human NK1 antagonists. | ||||
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