| Drug General Information |
| Drug ID |
D04TTP
|
| Former ID |
DNC008127
|
| Drug Name |
5,7-dibromo-9H-pyrido[3,4-b]indol-6-ol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C11H6Br2N2O
|
| Canonical SMILES |
C1=CN=CC2=C1C3=C(C(=C(C=C3N2)Br)O)Br
|
| InChI |
1S/C11H6Br2N2O/c12-6-3-7-9(10(13)11(6)16)5-1-2-14-4-8(5)15-7/h1-4,15-16H
|
| InChIKey |
UNIUKKWPGRGSRQ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Adenosine A3 receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Adenosine A2a receptor |
Target Info |
Inhibitor |
[1]
|
| Adenosine A1 receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
|
cAMP signaling pathway
|
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Neuroactive ligand-receptor interaction
|
|
Vascular smooth muscle contraction
|
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Parkinson's disease
|
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Alcoholismhsa04022:cGMP-PKG signaling pathway
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Sphingolipid signaling pathway
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Morphine addiction
|
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NetPath Pathway
|
TCR Signaling Pathway
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RANKL Signaling Pathway
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PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Pathway Interaction Database
|
HIF-2-alpha transcription factor network
|
|
PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
|
Reactome
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Adenosine P1 receptors
|
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G alpha (i) signalling eventsR-HSA-187024:NGF-independant TRKA activation
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G alpha (s) signalling events
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Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Nucleotide GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
GPCRs, OtherWP80:Nucleotide GPCRs
|
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Monoamine Transport
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NGF signalling via TRKA from the plasma membrane
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GPCR ligand binding
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|
GPCR downstream signaling
|
| References |
| REF 1 | Bioorg Med Chem. 2008 Apr 1;16(7):3825-30. Epub 2008 Jan 30.Synthesis of eudistomin D analogues and its effects on adenosine receptors. |
|---|
