Drug Information

Drug General Information
Drug ID
D04SPK
Former ID
DCL000326
Drug Name
Seratrodast
Synonyms
Bronica; A 73001; AA 2414; ABT 001; Abbott 73001; A-73001; AA-2414; ABT-001; Abbott-73001; Bronica (TN); Seratrodast [USAN:INN]; Seratrodast (JAN/USAN/INN); (+-)-2,4,5-Trimethyl-3,6-dioxo-zeta-phenyl-1,4-cyclohexadiene-1-heptanoic acid; (+-)-7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid; 7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid; 7-phenyl-7-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)heptanoic acid
Drug Type
Small molecular drug
Indication Allergic asthma [ICD9: 493, 995.3; ICD10:J45, T78.4] Discontinued in Phase 3 [536361]
Company
Takeda Pharma
Structure
Download
2D MOL

3D MOL
Formula
C22H26O4
Canonical SMILES
CC1=C(C(=O)C(=C(C1=O)C)C(CCCCCC(=O)O)C2=CC=CC=C2)C
InChI
1S/C22H26O4/c1-14-15(2)22(26)20(16(3)21(14)25)18(17-10-6-4-7-11-17)12-8-5-9-13-19(23)24/h4,6-7,10-11,18H,5,8-9,12-13H2,1-3H3,(H,23,24)
InChIKey
ZBVKEHDGYSLCCC-UHFFFAOYSA-N
CAS Number
CAS 112665-43-7
PubChem Compound ID
2449
PubChem Substance ID
5584519, 7848186, 7980464, 8151634, 12013832, 14876439, 29221613, 48414587, 49830166, 49880326, 50125893, 57321321, 74807047, 81094522, 85210460, 91615962, 103267220, 103808130, 104300620, 117584139, 121362280, 126671552, 129880275, 131294765, 134224157, 134338980, 134340368, 135017832, 135371343, 135697578, 137010169, 137619469, 144076118, 144206327, 152051244, 162011717, 162176641, 162311097, 162776232, 164233644, 164814859, 165235264, 166226111, 170465940, 175607568, 179148424, 184546209, 204380861, 210279852, 210282175
SuperDrug ATC ID
R03DX06
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Antagonist [535888]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 535888Thromboxane A2 inhibition: therapeutic potential in bronchial asthma. Am J Respir Med. 2002;1(1):11-7.

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