Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04RUP
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| Former ID |
DIB001543
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| Drug Name |
SDZ-NKT-343
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| Synonyms |
NKT-343; SDZ-250343
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| Drug Type |
Small molecular drug
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| Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Discontinued in Phase 1 | [1] | ||
| Company |
Novartis AG
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| Structure |
|
Download2D MOL |
|||
| Formula |
C33H33N5O5
|
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| Canonical SMILES |
C(=O)(N1[C@H](C(=O)N[C@H](C(=O)N(Cc2ccccc2)C)Cc2cc3c(cc<br />2)cccc3)CCC1)Nc1c([N+](=O)[O-])cccc1
|
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| CAS Number |
CAS 180046-99-5
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Substance-P receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Measles | |||||
| PANTHER Pathway | CCKR signaling map ST | ||||
| Reactome | G alpha (q) signalling events | ||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Spinal Cord Injury | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010524) | ||||
| REF 2 | The effects of SDZ NKT 343, a potent NK1 receptor antagonist, on cutaneous responses of primate spinothalamic tract neurones sensitized by intradermal capsaicin injection. Exp Brain Res. 1998 Aug;121(3):355-8. | ||||
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