Drug General Information
Drug ID	D04RBQ
Former ID	DNC012768
Drug Name	1,2,3,4-Tetrahydro-benzo[h]isoquinolin-8-ol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534531]
Structure		Download 2D MOL 3D MOL
Formula	C13H13NO
Canonical SMILES	C1CNCC2=C1C=CC3=C2C=CC(=C3)O
InChI	1S/C13H13NO/c15-11-3-4-12-10(7-11)2-1-9-5-6-14-8-13(9)12/h1-4,7,14-15H,5-6,8H2
InChIKey	MWWTWCVGHVVXBZ-UHFFFAOYSA-N
PubChem Compound ID	9990355
Target and Pathway
Target(s)	Alpha-2B adrenergic receptor	Target Info	Inhibitor	[534531]
	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[534531]
	Alpha-2C adrenergic receptor	Target Info	Inhibitor	[534531]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	G alpha (i) signalling events
	G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-390696:Adrenoceptors
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	Integration of energy metabolism
	GPCR downstream signaling
References
Ref 534531	J Med Chem. 1997 Dec 5;40(25):3997-4005.Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the alpha 2-adrenoceptor.
Ref 534531	J Med Chem. 1997 Dec 5;40(25):3997-4005.Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the alpha 2-adrenoceptor.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.