Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04QUX
|
||||
| Former ID |
DIB011713
|
||||
| Drug Name |
PF-446687
|
||||
| Synonyms |
PF-00446687; PF-2336652
|
||||
| Indication | Female sexual dysfunction [ICD9: 302.7; ICD10:F52] | Phase 2 | [1] | ||
| Company |
Pfizer Inc
|
||||
| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
[C@@H]1([C@@H](CN(C1)C(C)(C)C)c1ccc(cc1F)F)C(=O)N1C[C@H<br />]([C@](c2ccccc2)([C@H](C1)C)O)C.Cl
|
||||
| Target and Pathway | |||||
| Target(s) | Melanocortin-4 receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Pathway Interaction Database | Syndecan-3-mediated signaling events | ||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00862888) Study to Investigate Effect of a New Drug (PF-00446687) in Males Suffering From Erectile Dysfunction. U.S. National Institutes of Health. | ||||
| REF 2 | Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole. Neuropsychopharmacology. 2015 Jul;40(8):1856-65. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.