Drug Information

Drug General Information
Drug ID
D04QRM
Former ID
DIB020316
Drug Name
ME0328
Synonyms
ME-0328; compound 5b [PMID 24188023]
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532533]
Structure
Download
2D MOL

3D MOL
Formula
C19H19N3O2
InChI
InChI=1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)20-18(23)12-11-17-21-16-10-6-5-9-15(16)19(24)22-17/h2-10,13H,11-12H2,1H3,(H,20,23)(H,21,22,24)/t13-/m0/s1
InChIKey
QIHBWVVVRYYYRO-ZDUSSCGKSA-N
PubChem Compound ID
71571526
PubChem Substance ID
163614905, 172098849, 175440770, 175444445, 194172944, 208265344, 241377308, 249661310, 252158564, 252166678, 252450350, 252472394
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [532533]
poly (ADP-ribose) polymerase 3 Target Info Inhibitor [532533]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 532533Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3. J Med Chem. 2013 Dec 12;56(23):9556-68.
Ref 532533Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3. J Med Chem. 2013 Dec 12;56(23):9556-68.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.