Drug Information

Drug General Information
Drug ID
D04QJD
Former ID
DAP000643
Drug Name
Valaciclovir
Synonyms
Talavir; VACV; ValACV; Valacyclovir; Valtrex; Virval; Zelitrex; Valaciclovir Hcl; Valacyclover Hydrochloric; Valacyclover Hydrochloride; BW256U87; TBB067866; Acyclovir-valine; BW-256U; Valaciclovir (INN); Valaciclovir [INN:BAN]; Valaciclovir, Valtrex; Valtrex (TN); Zelitrex (TN); Valacyclovir, (L)-isomer; L-Valine ester with 9-((2-hydroxyethoxy)methyl)guanine; L-Valine, 2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester; L-valine, 2-[(2-amino-1,6-dihydro-6-oxo-9 H-purin-9-yl)methoxy]ethyl ester, monohydrochloride; 2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl L-valinate; 2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]ethyl (2S)-2-amino-3-methylbutanoate; 2-{[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]oxy}ethyl L-valinate
Drug Type
Small molecular drug
Indication Viral infections [ICD9: 054.0, 054.1, 054.2, 054.3, 075, 771.2, 052, 053; ICD10:B01, B02, A60, B00, B27, G05.1, P35.2] Approved [468056], [536361]
Therapeutic Class
Antiviral Agents
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C13H20N6O4
InChI
InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1
InChIKey
HDOVUKNUBWVHOX-QMMMGPOBSA-N
CAS Number
CAS 124832-27-5
PubChem Compound ID
60773
PubChem Substance ID
626316, 7980871, 12014356, 14718342, 14777186, 14801572, 14850688, 14850689, 14874889, 15940044, 29215498, 43118121, 46508197, 47589092, 48416691, 50062212, 56422581, 57314102, 78076275, 85279714, 85789653, 89736139, 92309076, 92710527, 96025347, 99775325, 103440109, 104048282, 104178841, 104321602, 117583422, 118313436, 124800881, 126631789, 126658129, 126682447, 128045545, 131905333, 134213320, 134221757, 134337933, 135030189, 135659820, 137005923, 137005924, 142590832, 160963922, 162782405, 163231563, 163621098
SuperDrug ATC ID
J05AB11
SuperDrug CAS ID
cas=124832264
Target and Pathway
Target(s) DNA polymerase Target Info Inhibitor [537100]
References
Ref 468056(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4824).
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 537100Extensive oral shedding of human herpesvirus 8 in a renal allograft recipient. Oral Microbiol Immunol. 2009 Apr;24(2):109-15.

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