Drug General Information
Drug ID	D04PWT
Former ID	DNCL001897
Drug Name	DP-b99
Drug Type	Small molecular drug
Indication	Stroke [ICD9: 434.91, 437.6, 453, 671.5, 671.9; ICD10:I61-I63, I80-I82]		Phase 3	[522654]
Company	D-Pharm
Structure		Download 2D MOL 3D MOL
Formula	C42H64N2O12
Canonical SMILES	CCCCCCCCOCCOC(=O)CN(CC(=O)O)C1=CC=CC=C1OCCOC2=CC=CC=C2N<br />(CC(=O)O)CC(=O)OCCOCCCCCCCC
InChIKey	FTGBVHPWUIHWRH-UHFFFAOYSA-N
PubChem Compound ID	9810955
PubChem Substance ID	14766936, 24117115, 44846939, 76858831, 135263163, 227009000, 243459021, 252215310
Target and Pathway
Target(s)	MMP-9	Target Info	Inhibitor	[532838]
KEGG Pathway	TNF signaling pathway
	Leukocyte transendothelial migration
	Estrogen signaling pathway
	Hepatitis B
	Pathways in cancer
	Transcriptional misregulation in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
	Bladder cancer
NetPath Pathway	ID Signaling Pathway
	TWEAK Signaling Pathway
	Leptin Signaling Pathway
	TNFalpha Signaling Pathway
PANTHER Pathway	Alzheimer disease-presenilin pathway
	Plasminogen activating cascade
	CCKR signaling map ST
Pathway Interaction Database	LPA receptor mediated events
	Plasma membrane estrogen receptor signaling
	Osteopontin-mediated events
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	Validated targets of C-MYC transcriptional activation
	CXCR4-mediated signaling events
	amb2 Integrin signaling
	Syndecan-4-mediated signaling events
	AP-1 transcription factor network
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	Syndecan-1-mediated signaling events
	Regulation of nuclear beta catenin signaling and target gene transcription
	FGF signaling pathway
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Assembly of collagen fibrils and other multimeric structures
	EPH-ephrin mediated repulsion of cells
WikiPathways	Endochondral Ossification
	IL1 and megakaryotyces in obesity
	Mammary gland development pathway - Involution (Stage 4 of 4)
	Activation of Matrix Metalloproteinases
	Degradation of collagen
	Spinal Cord Injury
	AGE/RAGE pathway
	TWEAK Signaling Pathway
	Angiogenesis
	Osteopontin Signaling
	Matrix Metalloproteinases
References
Ref 522654	ClinicalTrials.gov (NCT00893867) Efficacy and Safety Study of DP-b99 in Treating Acute Ischemic Stroke. U.S. National Institutes of Health.
Ref 532838	DP-b99 modulates matrix metalloproteinase activity and neuronal plasticity. PLoS One. 2014 Jun 11;9(6):e99789.

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