Drug Information

Drug General Information
Drug ID
D04PLI
Former ID
DCL000999
Drug Name
SR46349B
Synonyms
Eplivanserin fumarate; SR 46349; SR 46349B; SR-46349B; (E)-but-2-enedioic acid; 2-Propen-1-one, 1-(2-fluorophenyl)-3-(4-hydroxyphenyl)-, O-(2-(dimethylamino)ethyl)oxime, (Z,E)-, (E)-2-butenedioate (2:1) (salt); 4-((3Z)-3-(2-Dimethylaminoethyl)oxyimino-3-(2-fluorophenyl)propen-1-yl)phenol hemifumarate; 4-[(E)-3-(2-dimethylaminoethyloxyamino)-3-(2-fluorophenyl)prop-2-enylidene]cyclohexa-2,5-dien-1-one
Drug Type
Small molecular drug
Indication Sleep initiation and maintenance disorders; Primary insomnia; Schizophrenia [ICD9: 295, 307.41, 307.42, 327.0, 780.51, 780.52; ICD10:F20, F51.0, G47.0] Phase 3 [536463]
Company
Sanofi-Aventis
Structure
Download
2D MOL

3D MOL
Formula
C42H46F2N4O8
Canonical SMILES
CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=<br />CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O
InChI
1S/2C19H21FN2O2.C4H4O4/c2*1-22(2)13-14-24-21-19(17-5-3-4-6-18(17)20)12-9-15-7-10-16(23)11-8-15;5-3(6)1-2-4(7)8/h2*3-12,21H,13-14H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b2*19-12+;2-1+
InChIKey
UCLIFEBROADCQW-PWERMGERSA-N
PubChem Compound ID
6438382
PubChem Substance ID
14889094, 43031388, 50067967, 57368033, 75164580, 114555986, 126671673, 134224302, 135077957, 137267394, 160681717, 179293838, 223657465, 226973682, 249691353, 249896010, 252158495
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Modulator
5-hydroxytryptamine 2C receptor Target Info Modulator
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.

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