Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04MPB
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| Former ID |
DIB009821
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| Drug Name |
Bevirimat
|
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| Synonyms |
DSB; Bevirimat dimeglumine; DSB 2NMG; MPC-4326; PA-457; PA-103001-01; PA-103001-04; PA-457 di-NMG; Viral maturation inhibitor (HIV), Myrexis; Viral maturation inhibitor (HIV), Myriad; Viral maturation inhibitor (HIV), Panacos; YK-FH-312; 3-O-(3' 3'-dimethylsuccinyl)-betulinic acid
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| Drug Type |
Small molecular drug
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| Indication | Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] | Phase 2 | [522771] | ||
| Company |
Panacos
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| Structure |
|
Download2D MOL |
|||
| Formula |
C36H56O6
|
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| Canonical SMILES |
[C@@]12([C@]3([C@@H]([C@@]4([C@H](C([C@@H](OC(=O)CC(C(=<br />O)O)(C)C)CC4)(C)C)CC3)C)CC[C@@H]1[C@@H]1[C@@](C(=O)O)(C<br />C2)CC[C@H]1C(=C)C)C)C
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | HIV GAG protein | Target Info | Inhibitor | [532230] | |
| Reactome | Uncoating of the HIV Virion | ||||
| Budding and maturation of HIV virion | |||||
| Integration of provirus | |||||
| Early Phase of HIV Life Cycle | |||||
| Minus-strand DNA synthesis | |||||
| Plus-strand DNA synthesis | |||||
| 2-LTR circle formation | |||||
| Binding and entry of HIV virion | |||||
| Membrane binding and targetting of GAG proteins | |||||
| Assembly Of The HIV Virion | |||||
| Integration of viral DNA into host genomic DNA | |||||
| Autointegration results in viral DNA circles | |||||
| APOBEC3G mediated resistance to HIV-1 infection | |||||
| Vpr-mediated nuclear import of PICs | |||||
| WikiPathways | Host Interactions of HIV factors | ||||
| HIV Life Cycle | |||||
| References | |||||
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