Drug Information

Drug General Information
Drug ID
D04KKT
Former ID
DNC000815
Drug Name
ISO-1
Drug Type
Small molecular drug
Indication Discovery agent Phase 1 [524984]
Structure
Download
2D MOL

3D MOL
Formula
C9H13NO
Canonical SMILES
CC(C(C1=CC=CC=C1)O)N
InChI
1S/C9H13NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3/t7-,9-/m1/s1
InChIKey
DLNKOYKMWOXYQA-VXNVDRBHSA-N
CAS Number
CAS 27818-48-0
PubChem Compound ID
26934
PubChem Substance ID
5392, 75272, 8137967, 8169469, 11342205, 11362388, 11372611, 11375088, 11484207, 11487790, 11488332, 11491521, 11493499, 11537926, 16214245, 24859081, 26613190, 26679282, 34669514, 46508087, 47217075, 47589250, 47662556, 47811046, 48110751, 48259528, 48334800, 48416425, 49698998, 49998290, 49998467, 50065094, 50122763, 50122764, 56365833, 57310348, 75141456, 85789326, 93166534, 104224945, 104298649, 124637421, 125309883, 126524244, 126666496, 127752080, 134338176, 134340133, 134340378, 134989328
Target and Pathway
Target(s) Macrophage migration inhibitory factor Target Info Inhibitor [535444]
KEGG Pathway Tyrosine metabolism
Phenylalanine metabolism
PathWhiz Pathway Tyrosine Metabolism
WikiPathways Spinal Cord Injury
Adipogenesis
References
Ref 524984ClinicalTrials.gov (NCT02284919) [18F]ISO-1 PET/CT in Breast Cancer. U.S. National Institutes of Health.
Ref 535444The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277(28):24976-82. Epub 2002 May 7.

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