| Drug General Information |
| Drug ID |
D04KGP
|
| Former ID |
DNC009357
|
| Drug Name |
(R)-(-)-11-hydroxy-N-n-propylnoraporphine
|
| Synonyms |
11-Hydroxy-N-propylnoraporphine
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)O
|
| InChI |
1S/C19H21NO/c1-2-10-20-11-9-13-5-3-7-15-18(13)16(20)12-14-6-4-8-17(21)19(14)15/h3-8,16,21H,2,9-12H2,1H3/t16-/m1/s1
|
| InChIKey |
WZJSIHGOLMMBAL-MRXNPFEDSA-N
|
| Target and Pathway |
| Target(s) |
Dopamine D1 receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[2]
|
| D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Calcium signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Gap junction
|
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Dopaminergic synapse
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Parkinson's disease
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Cocaine addiction
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Amphetamine addiction
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Morphine addiction
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Alcoholismhsa04020:Calcium signaling pathway
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Serotonergic synapse
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Inflammatory mediator regulation of TRP channelshsa04015:Rap1 signaling pathway
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Alcoholism
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PANTHER Pathway
|
Dopamine receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathway
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PathWhiz Pathway
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Dopamine Activation of Neurological Reward System
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Reactome
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Dopamine receptors
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G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
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G alpha (q) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (i) signalling events
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WikiPathways
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Hypothetical Network for Drug Addiction
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Genes and (Common) Pathways Underlying Drug Addiction
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GPCR ligand binding
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GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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SIDS Susceptibility Pathways
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR downstream signaling
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GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
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Nicotine Activity on Dopaminergic Neurons
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| References |
| REF 1 | J Med Chem. 2008 Feb 28;51(4):983-7. Epub 2008 Feb 6.Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selectivity. |
|---|
| REF 2 | Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. Epub 2008 Aug 28.N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. |
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