TTD | Drug: D04KCT

Drug General Information
Drug ID	D04KCT
Former ID	DIB015361
Drug Name	Org-21465
Drug Type	Small molecular drug
Indication	Anesthesia [ICD9: 338; ICD10:R20.0]		Discontinued in Phase 1	[546127]
Company	Organon BioSciences
Structure		Download 2D MOL 3D MOL
Formula	C28H45NO7S
Canonical SMILES	[C@]12([C@H]([C@H]3[C@@H]([C@]4(C[C@H](N5CC(OCC5)(C)C)[<br />C@H](C[C@@H]4CC3)O)C)C(=O)C1)CC[C@@H]2C(=O)C)C
CAS Number	CAS 167946-96-5
PubChem Compound ID	10697702
Target and Pathway
Target(s)	GABA A receptor	Target Info	Modulator	[534520]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
Reactome	GABA A receptor activation
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transport
References
Ref 546127	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006459)
Ref 534520	Computer-controlled infusion of ORG 21465, a water soluble steroid i.v. anaesthetic agent, into human volunteers. Br J Anaesth. 1997 Oct;79(4):433-9.

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Drug Information