| Drug General Information |
| Drug ID |
D04JZV
|
| Former ID |
DNC002422
|
| Drug Name |
(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C9H15N5O3
|
| Canonical SMILES |
CC(C(C1CNC2=C(N1)C(=O)N=C(N2)N)O)O
|
| InChI |
1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)
|
| InChIKey |
FNKQXYHWGSIFBK-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
5642916, 7365597, 8143160, 8150986, 15315676, 16485349, 24439475, 46508597, 50027293, 53788135, 57320753, 79902430, 103378635, 103808147, 103876815, 103877952, 104296834, 117596589, 125334784, 126522962, 126652306, 127872327, 134337830, 134339769, 135023019, 137244978, 137251583, 142476107, 160963707, 179117143, 184548140, 196109799, 227735000, 234030764, 252146393
|
| Target and Pathway |
| Target(s) |
Nitric-oxide synthase, brain |
Target Info |
Inhibitor |
[1]
|
|---|
| Nitric oxide synthase, inducible |
Target Info |
Inhibitor |
[1]
|
| Nitric-oxide synthase, endothelial |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cycle
|
|
KEGG Pathway
|
Arginine and proline metabolism
|
|
Metabolic pathways
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Calcium signaling pathway
|
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Phagosome
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Circadian entrainment
|
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Long-term depression
|
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Salivary secretion
|
|
Alzheimer's disease
|
|
Amyotrophic lateral sclerosis (ALS)hsa00220:Arginine biosynthesis
|
|
HIF-1 signaling pathway
|
|
Peroxisome
|
|
Salmonella infection
|
|
Pertussis
|
|
Leishmaniasis
|
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Chagas disease (American trypanosomiasis)
|
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Toxoplasmosis
|
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Amoebiasis
|
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Tuberculosis
|
|
Pathways in cancer
|
|
Small cell lung cancerhsa00330:Arginine and proline metabolism
|
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cGMP-PKG signaling pathway
|
|
Sphingolipid signaling pathway
|
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PI3K-Akt signaling pathway
|
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VEGF signaling pathway
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Platelet activation
|
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Estrogen signaling pathway
|
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Oxytocin signaling pathway
|
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NetPath Pathway
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EGFR1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
|
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IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway
|
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PANTHER Pathway
|
CCKR signaling map STP00005:Angiogenesis
|
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Endothelin signaling pathway
|
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Interleukin signaling pathway
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PI3 kinase pathway
|
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VEGF signaling pathway
|
|
Pathway Interaction Database
|
IL12-mediated signaling events
|
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Alpha9 beta1 integrin signaling events
|
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ATF-2 transcription factor network
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IL23-mediated signaling events
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Signaling mediated by p38-alpha and p38-beta
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HIF-1-alpha transcription factor networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
|
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Validated transcriptional targets of AP1 family members Fra1 and Fra2
|
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Angiopoietin receptor Tie2-mediated signaling
|
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Thromboxane A2 receptor signaling
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SHP2 signaling
|
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VEGFR1 specific signals
|
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Signaling events mediated by VEGFR1 and VEGFR2
|
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PAR1-mediated thrombin signaling events
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PathWhiz Pathway
|
Arginine and Proline Metabolism
|
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Reactome
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ROS production in response to bacteria
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Nitric oxide stimulates guanylate cyclaseR-HSA-1222556:ROS production in response to bacteria
|
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Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
|
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eNOS activation
|
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Nitric oxide stimulates guanylate cyclase
|
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VEGFR2 mediated vascular permeability
|
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WikiPathways
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Monoamine Transport
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Myometrial Relaxation and Contraction Pathways
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Amyotrophic lateral sclerosis (ALS)
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Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
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Spinal Cord Injury
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Alzheimers Disease
|
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Effects of Nitric Oxide
|
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Serotonin Transporter ActivityWP619:Type II interferon signaling (IFNG)
|
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AGE/RAGE pathway
|
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Effects of Nitric OxideWP554:ACE Inhibitor Pathway
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EGF/EGFR Signaling Pathway
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JAK/STAT
|
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Corticotropin-releasing hormone
|
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Endothelin Pathways
|
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Leptin signaling pathway
|
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Metabolism of nitric oxide
|
|
Angiogenesis
|
| References |
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
|---|
