Drug Information
Drug General Information | |||||
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Drug ID |
D04JNI
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Former ID |
DCL000414
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Drug Name |
GSK2245840
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Drug Type |
Small molecular drug
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Indication | Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] | Phase 2 | [523097] | ||
Company |
GSK
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Structure |
Download2D MOL |
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Formula |
C19H30ClN5O2
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Canonical SMILES |
CC1(CC(=O)N(C(=O)C1)CCCCN2CCN(CC2)C3=NC=CC=N3)C.Cl
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InChI |
1S/C19H29N5O2.ClH/c1-19(2)14-16(25)24(17(26)15-19)9-4-3-8-22-10-12-23(13-11-22)18-20-6-5-7-21-18;/h5-7H,3-4,8-15H2,1-2H3;1H
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InChIKey |
DGOCVISYYYQFEP-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | NAD-dependent deacetylase sirtuin-1 | Target Info | Modulator | [533004], [533102] | |
PANTHER Pathway | p53 pathway | ||||
Pathway Interaction Database | p73 transcription factor network | ||||
Signaling events mediated by HDAC Class III | |||||
E2F transcription factor network | |||||
HIF-2-alpha transcription factor network | |||||
Signaling events mediated by HDAC Class I | |||||
FoxO family signaling | |||||
Regulation of Androgen receptor activity | |||||
Regulation of retinoblastoma protein | |||||
References |
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