Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04DMQ
|
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| Former ID |
DIB010695
|
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| Drug Name |
Fabesetron
|
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| Synonyms |
FK-1052
|
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| Drug Type |
Small molecular drug
|
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| Indication | Irritable bowel syndrome [ICD9: 564.1, 787.91; ICD10:A09, K58, K59.1] | Discontinued in Phase 2 | [1] | ||
| Company |
Fujisawa Pharmaceutical Co Ltd
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C18H19N3O
|
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| Canonical SMILES |
n12c(c(c3c2cccc3)C)CC[C@@H](C1=O)Cc1c(nc[nH]1)C.Cl
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 4 receptor | Target Info | Modulator | ||
| 5-HT 3 receptor | Target Info | Modulator | |||
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT4 type receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 4 and Serotonin | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001434) | ||||
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