Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04DMO
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| Former ID |
DIB005811
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| Drug Name |
FR-194738
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| Drug Type |
Small molecular drug
|
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| Indication | Hypercholesterolemia [ICD10:E78] | Terminated | [1] | ||
| Company |
Fujisawa Pharmaceutical Co Ltd
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C27H38ClNO2S
|
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| Canonical SMILES |
C(#CC(C)(C)C)/C=C/CN(Cc1cc(OCC(OCc2cscc2)(C)C)ccc1)CC.C<br />l
|
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| CAS Number |
CAS 204067-52-7
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Squalene monooxygenase | Target Info | Modulator | [2] | |
| KEGG Pathway | Steroid biosynthesis | ||||
| Sesquiterpenoid and triterpenoid biosynthesis | |||||
| Metabolic pathways | |||||
| Biosynthesis of secondary metabolites | |||||
| Biosynthesis of antibiotics | |||||
| PathWhiz Pathway | Steroid Biosynthesis | ||||
| Reactome | Cholesterol biosynthesis | ||||
| Activation of gene expression by SREBF (SREBP) | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009590) | ||||
| REF 2 | Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738. Bioorg Med Chem Lett. 2004 Feb 9;14(3):633-7. | ||||
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