Drug Information

Drug General Information
Drug ID
D04DJN
Former ID
DNC002525
Drug Name
Dihydrotestosterone
Drug Type
Small molecular drug
Indication Prostate hyperplasia [ICD10:N40] Phase 4 [521560], [539881]
Structure
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2D MOL

3D MOL
Formula
C19H30O2
InChI
InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1
InChIKey
NVKAWKQGWWIWPM-ABEVXSGRSA-N
CAS Number
CAS 521-18-6
PubChem Compound ID
10635
PubChem Substance ID
6646, 76024, 583926, 583927, 583928, 583929, 583930, 583932, 583933, 583934, 585358, 585359, 585360, 585692, 824234, 836816, 838818, 841438, 7887032, 7979089, 8145454, 8157682, 11532131, 12146093, 14751321, 14751322, 17389515, 24702282, 24891337, 25621350, 26707661, 26737076, 26737079, 26737083, 26737086, 26737089, 26737091, 26737094, 26737096, 26737098, 26737108, 26737500, 29229109, 38671806, 46392350, 46393206, 46393207, 46393212, 46518267, 48421870
Target and Pathway
Target(s) Androgen receptor Target Info Modulator
KEGG Pathway Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 521560ClinicalTrials.gov (NCT00062790) Effect Of Dutasteride On Intraprostatic Dihydrotestosterone (DHT) Levels. U.S. National Institutes of Health.
Ref 539881(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2856).

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