Drug Information

Drug General Information
Drug ID
D04CUA
Former ID
DIB019314
Drug Name
compound 1o
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532542]
Structure
Download
2D MOL
Formula
C24H27N7O
InChI
InChI=1S/C24H27N7O/c25-23-20(24-29-21-4-3-19(12-22(21)32-24)30-9-1-2-10-30)11-16(13-27-23)17-14-28-31(15-17)18-5-7-26-8-6-18/h3-4,11-15,18,26H,1-2,5-10H2,(H2,25,27)
InChIKey
MWVKLRSIDOXBSE-UHFFFAOYSA-N
PubChem Compound ID
44256277
PubChem Substance ID
177216001, 194173015, 194941986, 249565823
Target and Pathway
Target(s) G protein-coupled receptor kinase 5 Target Info Inhibitor [532542]
Beta-adrenergic receptor kinase 1 Target Info Inhibitor [532542]
Hepatocyte growth factor receptor Target Info Inhibitor [532542]
KEGG Pathway Chemokine signaling pathway
Endocytosis
Glutamatergic synapse
Morphine addictionhsa04014:Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Axon guidance
Focal adhesion
Adherens junction
Bacterial invasion of epithelial cells
Epithelial cell signaling in Helicobacter pylori infection
Malaria
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Melanoma
Central carbon metabolism in cancer
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Parkinson disease
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database Signaling events mediated by HDAC Class II
Thromboxane A2 receptor signaling
CXCR4-mediated signaling events
Signaling events mediated by the Hedgehog family
IL8- and CXCR1-mediated signaling eventsmet_pathway:Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Arf6 signaling events
Signaling events mediated by TCPTP
Posttranslational regulation of adherens junction stability and dissassembly
Direct p53 effectors
Syndecan-1-mediated signaling events
Stabilization and expansion of the E-cadherin adherens junction
a6b1 and a6b4 Integrin signaling
FGF signaling pathway
Regulation of retinoblastoma protein
Reactome Calmodulin induced events
G alpha (q) signalling events
Activation of SMOR-HSA-416550:Sema4D mediated inhibition of cell attachment and migration
WikiPathways Hedgehog Signaling Pathway
DAG and IP3 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Opioid Signalling
GPCR downstream signalingWP366:TGF beta Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Focal Adhesion
Extracellular vesicle-mediated signaling in recipient cells
Signaling Pathways in Glioblastoma
miR-targeted genes in squamous cell - TarBase
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
Semaphorin interactions
References
Ref 532542Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6711-6.
Ref 532542Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6711-6.

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