Drug Information

Drug General Information
Drug ID
D04BNM
Former ID
DNC014861
Drug Name
5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468239]
Structure
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2D MOL

3D MOL
Formula
C12H12Cl2N2O4
InChI
InChI=1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1
InChIKey
XHSQDZXAVJRBMX-DDHJBXDOSA-N
PubChem Compound ID
5894
PubChem Substance ID
598569, 8153647, 14923748, 24278361, 26683823, 29224921, 46511870, 47720224, 49882784, 53787056, 56463021, 57323027, 57654983, 71822673, 78194938, 87557378, 99350818, 99350819, 99444944, 103511359, 104310551, 124801296, 129690503, 134352066, 134971503, 137142262, 137923479, 139928731, 160969510, 164839842, 170482643, 170483349, 170483350, 178101868, 179236245, 184531847, 226443807, 241093254, 251963177, 252465579
Target and Pathway
Target(s) Casein kinase II, alpha chain Target Info Inhibitor [530101]
KEGG Pathway Ribosome biogenesis in eukaryotes
NF-kappa B signaling pathway
Wnt signaling pathway
Adherens junction
Tight junction
Measles
Herpes simplex infection
Epstein-Barr virus infection
NetPath Pathway FSH Signaling Pathway
Pathway Interaction Database BCR signaling pathway
Atypical NF-kappaB pathway
DNA-PK pathway in nonhomologous end joining
Presenilin action in Notch and Wnt signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
E-cadherin signaling in the nascent adherens junction
Lissencephaly gene (LIS1) in neuronal migration and development
PDGFR-alpha signaling pathway
Signaling mediated by p38-alpha and p38-beta
Alpha-synuclein signaling
Reactome Condensation of Prometaphase Chromosomes
WikiPathways Mitotic Prometaphase
BDNF signaling pathway
TNF alpha Signaling Pathway
L1CAM interactions
References
Ref 468239(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5178).
Ref 530101Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. Epub 2009 Apr 22.Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid.

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