Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04AZE
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| Former ID |
DIB020899
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| Drug Name |
SB 204741
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| Synonyms |
SB-204741; SB-204,741
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C14H14N4OS
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| InChI |
InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
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| InChIKey |
USFUFHFQWXDVMH-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
4319791, 7980565, 9253653, 11111772, 11114048, 14775544, 17404818, 24278321, 34681248, 46500468, 47720605, 48243358, 48393924, 50104824, 50104825, 53777361, 57356145, 78571073, 85209283, 85231216, 90341465, 91722264, 92303715, 103306199, 111825035, 121360876, 124749572, 124799681, 124881389, 124881390, 124881391, 129413203, 131300009, 134224560, 135650984, 135698267, 136351091, 162223685, 163124999, 163564209, 164339477, 164759361, 178125737, 179149979, 184560789, 196399655, 204360509, 223454816, 229399889, 241182372
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 2C receptor | Target Info | Antagonist | [2] | |
| 5-hydroxytryptamine 2B receptor | Target Info | Antagonist | [2] | ||
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Serotonergic synapse | |||||
| Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| PANTHER Pathway | 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors | |||||
| G alpha (q) signalling events | |||||
| WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 221). | ||||
| REF 2 | Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. Epub 2004 Jul 30. | ||||
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