| Drug General Information |
| Drug ID |
D04APY
|
| Former ID |
DIB008912
|
| Drug Name |
KC-11404
|
| Indication |
Asthma [ICD10:J45]
|
Terminated |
[1]
|
|---|
| Company |
Solvay Deutschland GmbH
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
n12c(c(c3c1c(cc(c3)O)CCC2CCCC)CCN1CCN(c2nccc(c2)C)CC1)C
|
| CAS Number |
CAS 148490-22-6
|
| Target and Pathway |
| Target(s) |
Arachidonate 5-lipoxygenase |
Target Info |
Modulator |
[1]
|
|---|
| Platelet-activating factor receptor |
Target Info |
Modulator |
[1]
|
|
BioCyc Pathway
|
Aspirin-triggered lipoxin biosynthesis
|
|
Resolvin D biosynthesis
|
|
Leukotriene biosynthesis
|
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Lipoxin biosynthesis
|
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Aspirin triggered resolvin D biosynthesis
|
|
Aspirin triggered resolvin E biosynthesis
|
|
KEGG Pathway
|
Arachidonic acid metabolism
|
|
Metabolic pathways
|
|
Serotonergic synapse
|
|
Ovarian steroidogenesis
|
|
Toxoplasmosishsa04020:Calcium signaling pathway
|
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Neuroactive ligand-receptor interaction
|
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Staphylococcus aureus infection
|
|
NetPath Pathway
|
IL4 Signaling PathwayNetPath_17:IL5 Signaling Pathway
|
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Leptin Signaling Pathway
|
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PathWhiz Pathway
|
Arachidonic Acid Metabolism
|
|
Reactome
|
Class A/1 (Rhodopsin-like receptors)
|
|
G alpha (q) signalling events
|
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Interferon gamma signaling
|
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WikiPathways
|
Vitamin D Receptor Pathway
|
|
Arachidonic acid metabolism
|
|
Eicosanoid Synthesis
|
|
Selenium Micronutrient NetworkWP455:GPCRs, Class A Rhodopsin-like
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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Small Ligand GPCRs
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Interferon gamma signaling
|
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GPCR ligand binding
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|
GPCR downstream signaling
|
| References |
| REF 1 | Synthesis, structure-activity relationships, and pharmacological evaluation of pyrrolo[3,2,1-ij]quinoline derivatives: potent histamine and platelet activating factor antagonism and 5-lipoxygenase inhibitory properties. Potential therapeutic application in asthma. J Med Chem. 1995 Feb 17;38(4):669-85. |
|---|
