TTD | Drug: D04ABS

Drug General Information
Drug ID	D04ABS
Former ID	DIB002742
Drug Name	CPH-102
Synonyms	IABP; CPH-102; INH2BP, Crimson Pharmaceutical; INH2BP, Octamer; PARP inhibitors, Crimson Pharmaceutical; PARP inhibitors, Octamer; CPH-101, Crimson Pharma
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Preclinical	[546143]
Company	Octamer Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c12ccc(=O)oc1ccc(c2I)N
CAS Number	CAS 137881-27-7
Target and Pathway
Target(s)	Poly [ADP-ribose] polymerase-1	Target Info	Inhibitor	[543709]
KEGG Pathway	Base excision repair
KEGG Pathway	NF-kappa B signaling pathway
PANTHER Pathway	FAS signaling pathway
Pathway Interaction Database	Integrin-linked kinase signaling
	Caspase Cascade in Apoptosis
	Notch-mediated HES/HEY network
Reactome	Dual Incision in GG-NER
WikiPathways	FAS pathway and Stress induction of HSP regulation
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Nanoparticle triggered regulated necrosis
	Corticotropin-releasing hormone
References
Ref 546143	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006586)
Ref 543709	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2771).

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Drug Information