| Drug General Information |
| Drug ID |
D04AAV
|
| Former ID |
DNC012005
|
| Drug Name |
2-(4-Diethylamino-but-2-ynyl)-isoindole-1,3-dione
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H18N2O2
|
| Canonical SMILES |
CCN(CC)CC#CCN1C(=O)C2=CC=CC=C2C1=O
|
| InChI |
1S/C16H18N2O2/c1-3-17(4-2)11-7-8-12-18-15(19)13-9-5-6-10-14(13)16(18)20/h5-6,9-10H,3-4,11-12H2,1-2H3
|
| InChIKey |
DEWGBLHKQDVWLX-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Muscarinic acetylcholine receptor M2 |
Target Info |
Inhibitor |
[1]
|
|---|
| Muscarinic acetylcholine receptor M1 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
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PI3K-Akt signaling pathway
|
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Cholinergic synapse
|
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Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
|
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Regulation of actin cytoskeleton
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PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
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PathWhiz Pathway
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Muscle/Heart Contraction
|
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Reactome
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Muscarinic acetylcholine receptors
|
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G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
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G alpha (q) signalling events
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WikiPathways
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SIDS Susceptibility Pathways
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Monoamine GPCRs
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Calcium Regulation in the Cardiac Cell
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Regulation of Actin Cytoskeleton
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signaling
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GPCRs, OtherWP58:Monoamine GPCRs
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Gastrin-CREB signalling pathway via PKC and MAPK
|
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Secretion of Hydrochloric Acid in Parietal Cells
|
| References |
| REF 1 | Design of dual acting anticonvulsant-antimuscarinic succinimide and hydantoin derivatives, Bioorg. Med. Chem. Lett. 7(8):979-984 (1997). |
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