Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03ZPX
|
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| Former ID |
DIB009459
|
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| Drug Name |
PRX-07034
|
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| Synonyms |
5-HT 6 antagonists (obesity/cognitive impairment), EPIX; 5-HT 6 antagonists (obesity/cognitive impairment), Predix
|
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| Drug Type |
Small molecular drug
|
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| Indication | Obesity [ICD9: 278; ICD10:E66] | Phase 1 | [1] | ||
| Company |
Epix Pharmaceutical
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| Structure |
|
Download2D MOL |
|||
| Formula |
C21H29Cl2N3O4S
|
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| Canonical SMILES |
c1c(c(c(cc1Cl)C(C)Nc1c(ccc(c1)N1CCNCC1)S(=O)(=O)C)OC)OC<br />.Cl
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 6 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021329) | ||||
| REF 2 | Low-dose prazosin in combination with 5-HT6 antagonist PRX-07034 has antipsychotic effects. Can J Physiol Pharmacol. 2015 Jan;93(1):13-21. | ||||
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