Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03YPJ
|
||||
| Former ID |
DNC001281
|
||||
| Drug Name |
SB 206553
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Discovery agent | Terminated | [1], [2] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C17H16N4O
|
||||
| InChI |
InChI=1S/C17H16N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22)
|
||||
| InChIKey |
QJQORSLQNXDVGE-UHFFFAOYSA-N
|
||||
| CAS Number |
CAS 214745-43-4
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID |
13905, 866556, 5591037, 7979278, 8153174, 11111766, 11114169, 14898053, 29224225, 47736664, 50104925, 57322635, 75242555, 85209908, 85789041, 90340847, 92729639, 103221386, 103847082, 103956180, 104308451, 117537767, 124750284, 124881377, 124881378, 129032563, 134338690, 134340487, 134340488, 134348480, 135650985, 137161672, 142945656, 162223686, 163146104, 174006270, 179150021, 196394253, 223259267, 223440902, 227667615
|
||||
| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 2B receptor | Target Info | Antagonist | [3] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Serotonergic synapse | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| PANTHER Pathway | 5HT2 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 189). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006211) | ||||
| REF 3 | Strain-dependent effects of diazepam and the 5-HT2B/2C receptor antagonist SB 206553 in spontaneously hypertensive and Lewis rats tested in the elevated plus-maze. Braz J Med Biol Res. 2001 May;34(5):675-82. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.