Drug Information

Drug General Information
Drug ID
D03XVJ
Former ID
DIB019052
Drug Name
C7/3-phth
Synonyms
heptane-1,7-bis(dimethyl-3'-phthalimidopropylammonium)
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542617]
Structure
Download
2D MOL
Formula
C33H46N4O4+2
InChI
InChI=1S/C33H46N4O4/c1-36(2,24-14-20-34-30(38)26-16-8-9-17-27(26)31(34)39)22-12-6-5-7-13-23-37(3,4)25-15-21-35-32(40)28-18-10-11-19-29(28)33(35)41/h8-11,16-19H,5-7,12-15,20-25H2,1-4H3/q+2
InChIKey
OSALRKZRWVYPFR-UHFFFAOYSA-N
PubChem Compound ID
168057
PubChem Substance ID
46241467, 76216414, 103095265, 103150947, 103202604, 103967775, 113462211, 117598395, 126446185, 128853521, 135122419, 223365969, 241041534
Target and Pathway
Target(s) Muscarinic receptor Target Info Modulator (allosteric modulator) [534816]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 542617(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7634).
Ref 534816Characterization of the subtype selectivity of the allosteric modulator heptane-1,7-bis-(dimethyl-3'-phthalimidopropyl) ammonium bromide (C7/3-phth) at cloned muscarinic acetylcholine receptors. Biochem Pharmacol. 1999 Jan 15;57(2):171-9.

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