Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03XUQ
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| Former ID |
DIB007317
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| Drug Name |
ABS-212
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| Synonyms |
Neurotensin derivative (pain), Argolyn
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| Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Terminated | [1], [2] | ||
| Company |
Argolyn Bioscience Inc
|
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
[C@@H]1(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)[O-])C<br />C(C)C)C(C)(C)C)Cc2ccc(cc2)O)CCCN1C(=O)[C@@H](NC(=O)[C@H<br />](CCC[N+](C)(C)C)C)CCCNC(=N)N
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| Target and Pathway | |||||
| Target(s) | Neurotensin receptor type 1 | Target Info | Agonist | [3] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5307). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026502) | ||||
| REF 3 | Identification and functional characterization of a stable, centrally active derivative of the neurotensin (8-13) fragment as a potential first-in-class analgesic. J Med Chem. 2010 Jun 24;53(12):4623-32. | ||||
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