Drug General Information
Drug ID	D03XHS
Former ID	DIB012795
Drug Name	ACT-178882
Synonyms	MK-1597
Indication	Cardiovascular disorder [ICD10:I00-I99]		Phase 1	[548839]
Company	Actelion Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1c(ccc(n1)OCCOc1c(cc(cc1Cl)C)Cl)[C@@H]1[C@H](CNCC1)C(=<br />O)N(C1CC1)Cc1c(ccc(c1)CCOC)Cl
Target and Pathway
Target(s)	Renin, renal	Target Info	Inhibitor	[532219]
KEGG Pathway	Renin-angiotensin system
PathWhiz Pathway	Angiotensin Metabolism
Reactome	Metabolism of Angiotensinogen to Angiotensins
WikiPathways	ACE Inhibitor Pathway
	Metabolism of Angiotensinogen to Angiotensins
References
Ref 548839	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029409)
Ref 532219	Drug-drug interaction study of ACT-178882, a new renin inhibitor, and diltiazem in healthy subjects. Clin Drug Investig. 2013 Mar;33(3):207-13.

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