Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03XBB
|
||||
| Former ID |
DIB012839
|
||||
| Drug Name |
DX-2400
|
||||
| Synonyms |
DX-2410; MMP inhibitors (fully human antibodies), Dyax
|
||||
| Indication | Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] | Investigative | [1] | ||
| Company |
Dyax Corp
|
||||
| Target and Pathway | |||||
| Target(s) | Matrix metalloproteinase-14 | Target Info | Inhibitor | [1] | |
| KEGG Pathway | TNF signaling pathway | ||||
| GnRH signaling pathway | |||||
| PANTHER Pathway | Alzheimer disease-presenilin pathway | ||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Signaling events mediated by focal adhesion kinase | |||||
| Reactome | Collagen degradation | ||||
| Degradation of the extracellular matrix | |||||
| Activation of Matrix Metalloproteinases | |||||
| WikiPathways | Senescence and Autophagy in Cancer | ||||
| Activation of Matrix Metalloproteinases | |||||
| Degradation of collagen | |||||
| AGE/RAGE pathway | |||||
| Matrix Metalloproteinases | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1638). | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.