Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03VRC
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| Former ID |
DNC010492
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| Drug Name |
1-(4-Bromobenzyl)-1H-imidazole
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [528335] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C10H9BrN2
|
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| Canonical SMILES |
C1=CC(=CC=C1CN2C=CN=C2)Br
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| InChI |
1S/C10H9BrN2/c11-10-3-1-9(2-4-10)7-13-6-5-12-8-13/h1-6,8H,7H2
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| InChIKey |
MZJSYLIOMLCYIS-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | 17 alpha-hydroxylase-C17, 20-lyase | Target Info | Inhibitor | [528335] | |
| Cytochrome P450 11B1, mitochondrial | Target Info | Inhibitor | [530679] | ||
| PathWhiz Pathway | Androgen and Estrogen Metabolism | ||||
| SteroidogenesisPW000141:Steroidogenesis | |||||
| WikiPathways | Metapathway biotransformation | ||||
| Steroid Biosynthesis | |||||
| Oxidation by Cytochrome P450 | |||||
| Metabolism of steroid hormones and vitamin D | |||||
| Glucocorticoid & Mineralcorticoid Metabolism | |||||
| Prostate Cancer | |||||
| Phase 1 - Functionalization of compoundsWP702:Metapathway biotransformation | |||||
| Corticotropin-releasing hormone | |||||
| References | |||||
| Ref 528335 | Bioorg Med Chem Lett. 2006 Sep 15;16(18):4752-6. Epub 2006 Jul 25.Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)). | ||||
| Ref 530679 | J Med Chem. 2010 Feb 25;53(4):1712-25.Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). | ||||
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