Drug General Information
Drug ID
D03VGO
Former ID
DIB019949
Drug Name
GSK2194069
Synonyms
GSK-2194069; GSK 2194069
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532905]
Structure
Download
2D MOL
Formula
C25H24N4O3
InChI
InChI=1S/C25H24N4O3/c30-24(18-1-2-18)28-11-9-16(15-28)13-23-26-27-25(31)29(23)21-6-3-17(4-7-21)19-5-8-22-20(14-19)10-12-32-22/h3-8,10,12,14,16,18H,1-2,9,11,13,15H2,(H,27,31)/t16-/m0/s1
InChIKey
AQTPWCUIYUOEMG-INIZCTEOSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Fatty acid synthase Target Info Inhibitor [532905]
BioCyc Pathway Fatty acid biosynthesis initiation
Fatty acid elongation -- saturated
Palmitate biosynthesis
KEGG Pathway Fatty acid biosynthesis
Metabolic pathways
Fatty acid metabolism
AMPK signaling pathway
Insulin signaling pathway
Pathway Interaction Database p73 transcription factor network
Validated transcriptional targets of deltaNp63 isoforms
PathWhiz Pathway Fatty Acid Biosynthesis
Reactome ChREBP activates metabolic gene expression
Activation of gene expression by SREBF (SREBP)
Fatty Acyl-CoA Biosynthesis
WikiPathways Fatty Acid Biosynthesis
Nuclear Receptors Meta-Pathway
Liver X Receptor Pathway
Activation of Gene Expression by SREBP (SREBF)
SREBF and miR33 in cholesterol and lipid homeostasis
SREBP signalling
Metabolism of water-soluble vitamins and cofactors
Integration of energy metabolism
Fatty acid, triacylglycerol, and ketone body metabolism
AMPK Signaling
References
Ref 532905A human fatty acid synthase inhibitor binds beta-ketoacyl reductase in the keto-substrate site. Nat Chem Biol. 2014 Sep;10(9):774-9.
Ref 532905A human fatty acid synthase inhibitor binds beta-ketoacyl reductase in the keto-substrate site. Nat Chem Biol. 2014 Sep;10(9):774-9.

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