Drug General Information
Drug ID	D03TYV
Former ID	DNC014386
Drug Name	5,5'-methylenebis(1,3,4-thiadiazole-2(3H)-thione)
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530900]
Structure		Download 2D MOL 3D MOL
Formula	C5H4N4S4
Canonical SMILES	C1=C(C(=C(C(=C1O)O)Br)Br)CC2=CC(=C(C(=C2Br)Br)O)O
InChI	1S/C13H8Br4O4/c14-8-4(2-6(18)12(20)10(8)16)1-5-3-7(19)13(21)11(17)9(5)15/h2-3,18-21H,1H2
InChIKey	WIAKRAUTQVUHHL-UHFFFAOYSA-N
PubChem Compound ID	46225958
Target and Pathway
Target(s)	Tyrosine oxidase	Target Info	Inhibitor	[530900]
BioCyc Pathway	(S)-reticuline biosynthesis
	Eumelanin biosynthesis
	L-dopachrome biosynthesis
KEGG Pathway	Tyrosine metabolism
	Riboflavin metabolism
	Metabolic pathways
	Melanogenesis
PathWhiz Pathway	Riboflavin Metabolism
	Tyrosine Metabolism
WikiPathways	Dopamine metabolism
References
Ref 530900	Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. Epub 2010 Apr 13.New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.
Ref 530900	Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. Epub 2010 Apr 13.New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.

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