Drug Information

Drug General Information
Drug ID
D03TQO
Former ID
DNC005974
Drug Name
6-(3-hydroxyphenyl)-2-morpholino-4H-chromen-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527888]
Structure
Download
2D MOL

3D MOL
Formula
C19H17NO4
Canonical SMILES
C1COCCN1C2=CC(=O)C3=C(O2)C=CC(=C3)C4=CC(=CC=C4)O
InChI
1S/C19H17NO4/c21-15-3-1-2-13(10-15)14-4-5-18-16(11-14)17(22)12-19(24-18)20-6-8-23-9-7-20/h1-5,10-12,21H,6-9H2
InChIKey
PLPMLPUPRLWRRG-UHFFFAOYSA-N
PubChem Compound ID
11558836
Target and Pathway
Target(s) DNA-dependent protein kinase catalytic subunit Target Info Inhibitor [527888]
KEGG Pathway Non-homologous end-joining
Cell cycle
NetPath Pathway IL1 Signaling Pathway
Pathway Interaction Database DNA-PK pathway in nonhomologous end joining
Coregulation of Androgen receptor activity
Class I PI3K signaling events mediated by Akt
BARD1 signaling events
Reactome Nonhomologous End-Joining (NHEJ)
WikiPathways DNA Damage Response
Non-homologous end joining
FAS pathway and Stress induction of HSP regulation
Cytosolic sensors of pathogen-associated DNA
Retinoblastoma (RB) in Cancer
Prostate Cancer
Double-Strand Break Repair
Cell Cycle
miRNA Regulation of DNA Damage Response
References
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.

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