Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03QXD
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| Former ID |
DIB004981
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| Drug Name |
RXP-470
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| Synonyms |
RXP-470; MMP-12 inhibitors (atherosclerosis); MMP-12 inhibitors (atherosclerosis), CEA; RXP-470 derivatives (atherosclerosis), CEA
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| Indication | Atherosclerosis [ICD9: 414.0, 440; ICD10:I70] | Investigative | [1] | ||
| Company |
Commissariat a l`Energie Atomique
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1(c2cc(on2)C[C@H](CP(=O)(O)c2ccc(cc2)Br)C(=O)N[C@H](C(<br />=O)N[C@H](C(=O)N)CCC(=O)O)CCC(=O)O)ccc(cc1)c1cccc(c1)Cl
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| Target and Pathway | |||||
| Target(s) | MMP-12 | Target Info | Inhibitor | [1] | |
| NetPath Pathway | IL1 Signaling Pathway | ||||
| IL5 Signaling Pathway | |||||
| Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | ||||
| Reactome | Collagen degradation | ||||
| Degradation of the extracellular matrix | |||||
| WikiPathways | TGF beta Signaling Pathway | ||||
| Degradation of collagen | |||||
| Matrix Metalloproteinases | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1636). | ||||
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