Drug Information

Drug General Information
Drug ID
D03QGL
Former ID
DNC004374
Drug Name
DALTROBAN
Drug Type
Small molecular drug
Indication Discovery agent Discontinued in Phase 3 [539283], [544557]
Structure
Download
2D MOL

3D MOL
Formula
C16H16ClNO4S
InChI
InChI=1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20)
InChIKey
IULOBWFWYDMECP-UHFFFAOYSA-N
PubChem Compound ID
54343
PubChem Substance ID
7980463, 8183594, 12013863, 14827916, 24724468, 29217545, 34718349, 47205878, 47731232, 47880083, 50064106, 50111705, 50291765, 57313603, 85208974, 103266899, 103916977, 104304662, 117609918, 125824441, 126651901, 126684326, 128222123, 134222427, 134341579, 135014547, 135065498, 135650157, 137035306, 144205815, 162178983, 162247901, 164175138, 164788317, 170466199, 172876507, 179151178, 184545795, 198977445, 223681779, 223860385, 226648554, 241138652, 242467035, 252347810, 252451135
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Inhibitor [527205]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 539283(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1986).
Ref 544557Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000129)
Ref 527205J Med Chem. 1992 Jun 12;35(12):2202-9.Synthesis and thromboxane A2/prostaglandin H2 receptor antagonistic activity of phenol derivatives.

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